Ultrastable mucoadhesive gold nanoparticles for corneal drug delivery
Increasing the corneal residence time of drugs is a current challenge in ophthalmology. Drug vectors with such properties can increase the efficiency of drugs, thereby reducing the frequency of administration, the duration of treatment, and the risk of post-surgical infection that may lead to sight loss.
The team of Prof Boisselier has developed a new ocular drug nanotechnology-based vector, in the form of ultrastable mucoadhesive gold nanoparticles onto which drugs can be encapsulated, to provide an efficient drug-vector formulation to delivering anti-inflammatory drugs, such as those prescribed after cataract surgery, to a mucoid surface such as the cornea.
Boisselier É, M Ouellette, V Pernet, and M Omar (2018). Ultrastable gold nanoparticles for drug delivery applications and synthesis thereof. Patent pending. Assignee: Université Laval
Boisselier É and D Astruc (2009). Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38: 1759-1782
Boisselier É, AK Diallo, L Salmon, C Ornelas, J Ruiz, and D Astruc (2010). Encapsulation and stabilization of gold nanoparticles with "click" polyethyleneglycol dendrimers. J Am Chem Soc 132: 2729-2742.
Boisselier É, AK Diallo, L Salmon, J Ruiz, and D Astruc (2008). Gold nanoparticles synthesis and stabilization via new "clicked" polyethyleneglycol dendrimers. Chem Commun (Camb) 2008: 4819-4821.
Boisselier É, L Salmon, J Ruiz, and D Astruc (2008). How to very efficiently functionalize gold nanoparticles by "click" chemistry. Chem Commun (Camb) 2008: 5788-5790.
Masse F, M Ouellette, G Lamoureux, and É Boisselier (2018). Gold nanoparticles in ophthalmology. Med Res Rev DOI: 10.1002/med.21509
Ultrastable mucoadhesive gold nanoparticules can efficiently deliver drugs to the cornea and significantly increase their residence time.
SOVAR and Université Laval seek a partner for co-development or commercialization of this technology for ophthalmic applications.
The laboratory of Prof Boisselier can synthesize, functionalize, and characterize ultrastable gold nanoparticles, as well as encapsultating drugs for in vitro and in vivo studies.