Novel pharmacological combination wound healing
The healing of corneal injuries and cataract surgeries generally requires 5-6 days, a period during which the risk of infection increases.
The group of Prof Guérin has demonstrated that the simultaneous modulation of CREB (inhibition by C646) and AKT (induction by SC79) signalling pathways can stimulate the growth of corneal cells, contributing to reduce the healing time to 4-5 days (rather than 6-7 days for controls) using a human tissue-engineered cornea in vitro model. This in vitro demonstration was reproduced in vivo in a rabbit ophthalmic injury disease model.
This innovation could have broad applications in wound healing using topical formulations.
Guérin S, L Germain, K Zaniolo, C Couture, and P Desjardins (2017-2019). Compositions favoring wound repair. WO2017075715A1, CA3003757A1, EP3370717A4, US20180318252A1. Assignee: Université Laval.
Couture C, P Desjardins, K Zaniolo, L Germain, and SL Guérin (2018). Enhanced wound healing of tissue-engineered human corneas through altered phosphorylation of the CREB and AKT signal transduction pathways. Acta Biomater 73: 312-325.
Masse F, P Desjardins, M Ouellette, C Couture, MM Omar, V Pernet, S Guérin and É Boisselier (2019). Synthesis of ultrastable gold nanoparticles as a new drug delivery system. Molecules 24: E2929.
The synergistic pharmacological combination of C646 and SC79 can accelerate corneal wound healing.
SOVAR and Université Laval seek a partner for co-development or commercialization of this technology, for evaluating more potent derivatives and/or developing a formulation to increase the corneal residence time.
The research group is fully capable of evaluating (formulated) compounds in vitro on tissue-engineered human corneas and in vivo in rabbits.